Urea (also known as Carbamide) is produced naturally by the skin and is part of the essential Natural Moisturizing Factor (NMF) which regulates skin’s moisture content. Urea is hygroscopic, which means it is able to bind moisture into the outermost layer of skin. It is also keratolytic, meaning helps the skin to get rid of dead skin cells dead skin cells, to make it smooth again, and has anti-itch and anti-microbial properties. As a result, it improves natural exfoliation and soothes and smoothes the skin’s surface. As a substance produced naturally by the skin, Urea is well-tolerated even by dry and sensitive skin. Because all of these effects and very good study data, Urea is the gold standard in treating of dry skin.*

^{* Reference: Augustin M et al., diagnosis and treatment of xerosis cutis – a position paper, JDDG 2019, DOI: 10.1111/ddg.13906}

Like Urea, Lactate (the salt of Lactic Acid) is also produced naturally by skin and is part of the Natural Moisturizing Factor (NMF) which regulates skin’s moisture content. Lactate absorbs and retains moisture within the stratum corneum, or upper layer of the skin, and therefore plays a vital role in maintaining the skin’s physical properties. Low levels of Lactate within the stratum corneum are known to be associated with dry skin.

Polidocanol is an antipruritic agent (something used to relieve itching) that has been clinically proven to soothe skin and help reduce itching.